Bone Abstracts

Effective treatments are available to reduce fracture risk in patients with postmenopausal osteoporosis. Though factors have been identified that modify the effect of treatment with one or more the currently available drugs, as a rule patients will benefit more from treatment the higher their base risk of fracture. From a societal and clinical point of view it is surprising that many guidelines for postmenopausal osteoporosis do not target treatment to patients at the highest ...

Background: Bisphosphonates are widely used to prevent and treat osteoporosis. Limited evidence suggest that these drugs may reduce mortality, perhaps by protecting against cardiovascular disease. This study investigated the occurrence of heart failure in patients treated with bisphosphonates.Methods: Nationwide retrospective cohort study from Denmark. All users of bisphosphonates and raloxifene (n=4.831) between 1996 and 2006 (n=102.34...

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Introduction: Osteoporotic fractures are known to be costly to society but estimates tend to be based on small scale prospective studies. In the following we report national data for healthcare costs due to fractures in patients with osteoporosis.Study population and methods: All Danish residents aged 35+, mean age 70.5 years, 13% men, 27.3% prior major osteoporotic fracture, who began bisphosphonates for osteoporosis between 1/1997 and 12/2002 (n</e...

see PP380....

Introduction: Communication of absolute and relative risks is challenging despite the development of tools to quickly derive absolute fracture risk estimates from risk factors with or without BMD. We speculated that back-transformation of risks to a risk age could make for a clearer message and at the same time increase agreement between risk algorithms.Results: The algorithms differed less in estimated bone health age than in percent risk. A 60 years ol...

The origin of the recent levelling-off in hip-fracture incidence in several settings is unknown.Methods: Using Danish national inpatient data for individuals aged ≥50 years during 1980–2010, we examined annual number and incidence of hip fractures and age, period, and cohort effects by log-likelihood estimates in Poisson regression models. Age adjustment was done by direct standardization, time-trend analysis by linear regression, and identifi...

Objective: The reasons for the recent decrease in hip fracture rates remain unclear. While current antiosteoporosis efforts are important also factors earlier in life seem essential and we examined age-period-cohort (APC) effects in hip fracture incidence in the Sweden (SE) and Denmark (DK).Material and Methods: We studied the entire populations aged &gE;50 years from 1987 to 2010 in SE and DK and ascertained acute hip fractures in nationwide discharge r...

Objective: To assess the relationship between thyrotoxicosis and osteoporotic fractures in men and women.Design: Register-based cohort study in patients with a TSH measurement in the region of Funen 1996–2010. All determinations were done in the same lab serving all hospitals and GP practices. Persons with raised TSH or a history of thyroid/pituitary disease were not included.Results: The study population consisted of 222 138 ...

Background: Improving the general population’s vitamin D status through food fortification is part of an ongoing debate. Vitamin D status during pregnancy may influence the long-term bone health of offspring; yet conflicting results have been reported and none of the studies have examined paediatric fracture as outcome.Method: The influence of extra vitamin D exposure during prenatal life and risk of fracture during adolescence was determined by com...